For decades, one name has been synonymous with the most respected, rigorous perspective on medical toxicology and treatment of poisoned and overdosed patient: Goldfrank's Toxicologic Emergencies. Presented in full color, Goldfrank's delivers essential, patient-centered coverage of every aspect of poison management. The editors and author are recognized as preeminent scholars in their specialties and provide unmatched coverage of all aspects of toxicologic emergencies, from pharmacology and clinical presentation to evidence-based treatment strategies. Fully referenced and featuring a consistent organization, Goldfrank's begins with an in-depth examination of general principles of medical toxicology. It then progresses to the biochemical principles of the molecular basis of toxicology, and provides detailed insight into how xenobiotics affect vital organs, and systems throughout the body, Next, a wide spectrum of clinically important exposures ' including drugs, plants, metals, household products, occupational and environmental xenobiotics and covered within logical categories for easy access of information. Finally, the book concludes with sections on principles of practicing clinical toxicology in today's challenging healthcare environment. All chapters have been thoroughly rewritten and updated with new content on medical, clinical, and chemical toxicology
1. Historical Principles and Perspectives Paul M. Wax 2. Toxicologic Misfortunes and Catastrophes in History Paul M. Wax PART A THE GENERAL APPROACH TO THE PATIENT 3. Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman 4. Principles of Managing the Acutely Poisoned or Overdosed Patient Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman [include eCPR, critical care dispositions] SC1. PRINCIPLES OF ANTIDOTE STOCKING 5. Decontamination Principles: Prevention of Gastrointestinal Absorption Lotte C. G. Hoegberg and Anne-Bolette Gude SC2. DECONTAMINATION PRINCIPLES: PREVENTION OF DERMAL, INHALATIONAL AND OCULAR ABSORPTION A1. ACTIVATED CHARCOAL Silas W. Smith and Mary Ann Howland A2. WHOLE-BOWEL IRRIGATION AND OTHER INTESTINAL EVACUANTS Silas W. Smith and Mary Ann Howland 6. Principles and Techniques Applied to Enhance Elimination David S. Goldfarb and Marc Ghannoum 7. Laboratory Principles Petrie M. Rainey 8. Principles of Diagnostic Imaging David T. Schwartz 9. Pharmacokinetic and Toxicokinetic Principles Mary Ann Howland PART B THE FUNDAMENTAL PRINCIPLES OF MEDICAL TOXICOLOGY SECTION I BIOCHEMICAL AND MOLECULAR CONCEPTS 10. Chemical Principles Stephen J. Traub and Lewis S. Nelson 11. Biochemical and Metabolic Principles Kurt C. Kleinschmidt and Kathleen A. Delaney 12. Fluid, Electrolyte, and Acid?Base Principles Alan N. Charney and Robert S. Hoffman 13. Neurotransmitters and Neuromodulators Steven C. Curry, Ayrn D. O'Connor, Kimberlie A. Graeme, Kirk C. Mills, and Aaron B. Skolnik 14. Withdrawal Principles Richard J. Hamilton and [new author] SECTION II PATHOPHYSIOLOGIC BASIS: ORGAN SYSTEMS 15. Cardiologic Principles I: Electrophysiologic and Electrocardiographic Principles Cathleen Clancy 16. Cardiologic Principles II: Hemodynamics Robert A. Hessler 17. Dermatologic Principles Jesse M. Lewin, Neal A. Lewin, and Lewis S. Nelson SC3. TRANSDERMAL TOXICOLOGY Lewis S. Nelson 18. Gastrointestinal Principles Matthew D. Zuckerman and Richard J. Church 19. Genitourinary Principles Jason Chu 20. Hematologic Principles Marco L.A. Sivilotti 21. Hepatic Principles Kathleen A. Delaney 22. Neurologic Principles Rama B. Rao 23. Oncologic Principles Richard Wang 24. Ophthalmic Principles Adhi Sharma 25. Otolaryngologic Principles William Chiang 26. Psychiatric Principles Erin A. Zerbo and Andrea M. Kondracke 27. Renal Principles Marc Ghannoum and David S. Goldfarb 28. Respiratory Principles Andrew Stolbach and Robert S. Hoffman 29. Thermoregulatory Principles Susi U. Vassallo and Kathleen A. Delaney SECTION III SPECIAL POPULATIONS 30. Reproductive and Perinatal Principles Jeffrey S. Fine 31. Pediatric Principles Jeffrey S. Fine 32. Geriatric Principles Judith C. Ahronheim and Mary Ann Howland PART C THE CLINICAL BASIS OF MEDICAL TOXICOLOGY SECTION I A. ANALGESICS AND ANTIINFLAMMATORY MEDICATIONS CASE STUDY 1 33. Acetaminophen Robert G. Hendrickson A3. N-ACETYLCYSTEINE Robert G. Hendrickson and Mary Ann Howland 34. Colchicine, Podophyllin, and the Vinca Alkaloids Joshua G. Schier 35. Nonsteroidal Antiinflammatory Drugs William J. Holubek 36. Opioids Lewis S. Nelson and Dean Olsen A4. OPIOID ANTAGONISTS Lewis S. Nelson and Mary Ann Howland SC4. INTERNAL CONCEALMENT OF XENOBIOTICS Jane M. Prosser SC5. HARM REDUCTION FOR OPIOID OVERDOSE Josh Lee 37. Salicylates Daniel M. Lugassy A5. SODIUM BICARBONATE Paul M. Wax B. FOOD, DIET, AND NUTRITION CASE STUDY 2 38. Botulism Howard L. Geyer A6. BOTULINUM ANTITOXIN Silas W. Smith and Howard L. Geyer 39. Food Poisoning Michael Tunik 40. Dieting Xenobiotics and Regimens Jeanna M. Marraffa 41. Athletic Performance Enhancers Susi U. Vassallo 42. Essential Oils Lauren Kornreich Shawn 43. Herbal Preparations Oliver Hung 44. Vitamins Beth Y. Ginsburg 45. Iron Jeanmarie Perrone A7. DEFEROXAMINE Mary Ann Howland C. PHARMACEUTICALS CASE STUDY 3 46. Pharmaceutical Additives Sean P. Nordt and Lisa E. Vivero 47. Antidiabetics and Hypoglycemics/Antiglycemics George M. Bosse A8. DEXTROSE (d-Glucose) Larissa Velez A9. OCTREOTIDE Mary Ann Howland and Silas W. Smith 48. Antiepileptics Suzanne Doyon A10. L-carnitine Mary Ann Howland 49. Antihistamines and Decongestants Sophie Gosselin A11. PHYSOSTIGMINE SALICYLATE